VITAMIN D3 INDUCES MESENCHYMAL-TO-ENDOTHELIAL TRANSITION AND PROMOTES A PROANGIOGENIC NICHE THROUGH IGF-1 SIGNALING

Vitamin D3 induces mesenchymal-to-endothelial transition and promotes a proangiogenic niche through IGF-1 signaling

Summary: Although vitamin D3 (VitD3) prevents angiogenesis in cancer, VitD3 deficiency is associated with greater incidence of cardiovascular events in patients.We examined the influence of VitD3 FRENCH ÉPICERIE on the angiogenic potential of mesenchymal stem cells (MSCs).VitD3 treatment increased the expression of proangiogenic molecules in MSCs,

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A leap towards enforcing medicines prescribing by generic names in low- and middle-income countries (LMICs): pitfalls, limitations, and recommendations for local drug regulatory agencies

The Drug Regulatory Authority of Pakistan (DRAP) in response to the public outcry on increasing medicines prices in the country issued notifications to direct healthcare professionals to prescribe medicines with their generic names.Like DRAP, many regulators in the low- and middle-income countries (LMICs) are also inspiring from the west to legally

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Screening and assessment for post-acute COVID-19 syndrome (PACS), guidance by personal pilots and support with individual digital trainings within intersectoral care: a study protocol of a randomized controlled trial

Abstract Background Because the clinical patterns and symptoms that persist after a COVID-19 infection are diverse, a diagnosis of post-acute COVID-19 syndrome (PACS) is difficult to implement.The current research project therefore aims to evaluate the feasibility and the practicability of a comprehensive, interdisciplinary, and cross-sectoral trea

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Exploring Chronic Pain in Hemodialysis Patients: An Observational Study Based on the New IASP Classification for ICD-11

Abstract Introduction Pain is one of the most frequently reported symptoms in hemodialyzed (HD) patients, with prevalence rates between 33% and 82%.Risk factors for chronic pain in HD patients are older age, long-lasting dialysis history, several concomitant diseases, malnutrition, and others.However, chronic pain assessment in HD patients is rarel

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